The decidual prolactin receptor and its regulation by decidua-derived factors
نویسندگان
چکیده
منابع مشابه
Expression of decidual prolactin-related protein in the rat decidua.
It is well established that rat decidual tissue produces a PRL-like hormone(s) that binds to the PRL receptor on both the corpus luteum and the decidual cells and initiates profound changes in the endocrine milieu required for the establishment of pregnancy. The recent cloning of a decidual PRL-related protein (dPRP) prompted us 1) to determine whether the expression of this gene is triggered b...
متن کاملExpression of prolactin-releasing peptide and its receptor in the human decidua.
Human decidua and decidualized endometrial cells produce prolactin (PRL). Several growth factors and cytokines have been shown to regulate decidual PRL release, but a specific PRL-releasing substance remains to be characterized. Prolactin-releasing peptide (PrRP) is a peptide isolated from the brain and distinguished by its potent and specific stimulation of PRL release by cultured pituitary ce...
متن کاملRat Decidual Prolactin
Establishment and maintenance of pregnancy require the activity of a highly specialized maternal tissue, the decidua. It is well established that the human decidua synthesizes and releases prolactin. However, in the rat, no study has been able to demonstrate the production of prolactin by the decidua. In this report, we established for the first time using Northern blot analysis and reverse tra...
متن کاملTissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin.
Prolactin (PRL) acts through its receptor (PRLR) via both endocrine and local paracrine/autocrine pathways to regulate biological processes including reproduction and lactation. We analyzed the tissue- and stage of gestation-specific regulation of PRL and PRLR expression in various tissues of pigs. Abundance of pPRLR-long form (LF) mRNA increased in the mammary gland and endometrium during gest...
متن کاملAn Ets motif in the proximal decidual prolactin promoter is essential for basal gene expression.
Transcriptional regulation of the prolactin gene in the decidua differs from that in the pituitary. Several lines of evidence strongly suggest this difference is due to regulation of the prolactin gene in the decidua and other extra-pituitary tissues by tissue-specific transcription factors, which activate distinct promoters to induce prolactin gene expression in extra-pituitary sites compared ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1996
ISSN: 0013-7227
DOI: 10.1210/en.137.11.4878